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Editors' Choice

John F. Foley
1 September 2009: ec288.
Small RNAs can be transferred between human B cell and T cell lines in a cell contact–dependent manner. Abstract »  
Wei Wong
1 September 2009: ec289.
Riboflavin kinase provides a cofactor for NADPH oxidase and recruits it to tumor necrosis factor receptor 1. Abstract »  
Annalisa M. VanHook
1 September 2009: ec290.
Cilia are required for maximal Hedgehog, but not Wnt, signaling in zebrafish. Abstract »  
Stella M. Hurtley
1 September 2009: ec291.
Airway epithelia directly sense and respond to noxious substances. Abstract »  
Elizabeth M. Adler
1 September 2009: ec292.
TREK1 and TREK2 channels show opposite responses to changes in external pH. Abstract »  
L. Bryan Ray
1 September 2009: ec293.
Localization and activation of signaling proteins in cancer cells are controlled by ubiquitin labeling. Abstract »  
Kristen Mueller
1 September 2009: ec294.
A transcription factor required for gene suppression in regulatory T cells is identified. Abstract »  


Research Articles

Travis J. Jerde and Wade Bushman
1 September 2009: ra49.
A classically inflammatory mediator, interleukin-1, also functions during development in the prostate. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Reuben J. Shaw
1 September 2009: pe55.
Salt-inducible kinase 1 is activated by LKB1 to promote anoikis, thereby blocking metastasis. Abstract »   Full Text »   PDF »  



Eric M. Prager and Luke R. Johnson
1 September 2009: re5.
Adrenal steroids regulate neuronal excitability by altering ion channel conductance or gene transcription. Gloss »   Abstract »   Full Text »   PDF »  



Guylène Firaguay and Jacques A. Nunès
1 September 2009: pl3.
State-specific antibodies combined with flow cytometry detect the activity of signaling pathways. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882