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Editors' Choice

Wei Wong
8 September 2009: ec295.
T cells release Wnt10b in response to intermittent parathyroid hormone to stimulate bone formation. Abstract »  
Nancy R. Gough
8 September 2009: ec296.
The cAMP pathway appears to mediate both activation and deactivation of the transcription factor Phox2a. Abstract »  
L. Bryan Ray
8 September 2009: ec297.
Cancer cell growth is stimulated by the inhibition of a previously unknown step in cell signaling for tumor suppression. Abstract »  
Guy Riddihough
8 September 2009: ec298.
A chromatin remodeling complex targeted by poly(ADP ribosyl)ation plays a role in DNA repair. Abstract »  
L. Bryan Ray
8 September 2009: ec299.
A phospholipid that binds to nuclear enzymes modifies gene transcription in response to external stimuli. Abstract »  
Stella M. Hurtley
8 September 2009: ec300.
Development of sensory bristles in flies depends on controlling the colocalization of actin assembly on membranes. Abstract »  
L. Bryan Ray
8 September 2009: ec301.
Release of a proteoglycan at sites of tissue damage can activate the innate immune system. Abstract »  



Sachdev S. Sidhu and Annalisa M. VanHook
8 September 2009: pc16.
Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities. Abstract »   Full Text »   Podcast »  


Research Articles

Andreas Ernst, Stephen L. Sazinsky, Shirley Hui, Bridget Currell, Moyez Dharsee, Somasekar Seshagiri, Gary D. Bader, and Sachdev S. Sidhu
8 September 2009: ra50.
Synthetic PDZ domain variants with random mutations reveal the remarkable robustness of this domain for ligand recognition. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Jonathan D. Humphries, Adam Byron, Mark D. Bass, Sue E. Craig, John W. Pinney, David Knight, and Martin J. Humphries
8 September 2009: ra51.
Regulator of chromosome condensation–2 is a component of fibronectin-activated signaling pathways that regulate cell migration. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Toshiki Itoh, Junya Hasegawa, Kazuya Tsujita, Yasunori Kanaho, and Tadaomi Takenawa
8 September 2009: ra52.
Changes in membrane composition stimulate Fer activity to regulate actin remodeling and drive cell migration. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Paul H. Huang, Alexander M. Xu, and Forest M. White
8 September 2009: re6.
EGFR and downstream signaling networks contribute to the hallmark characteristics of glioma. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882