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Editors' Choice

John F. Foley
15 September 2009: ec302.
ATP and UTP released from apoptotic cells recruit the macrophages necessary for their clearance. Abstract »  
Caroline Ash
15 September 2009: ec303.
Bacteria deploy nitric oxide synthases to counter oxidative stress from natural toxins and antibiotic drugs. Abstract »  
Nancy R. Gough
15 September 2009: ec304.
Comparison of the structure of ErbB2 with Drosophila epidermal growth factor receptor suggests that both may be autoinhibited in the absence of ligand. Abstract »  
L. Bryan Ray
15 September 2009: ec305.
Crystal structures reveal the mechanism of a nucleotide exchange factor regulating cytoskeleton and cell signaling networks. Abstract »  
Elizabeth M. Adler
15 September 2009: ec306.
The mitotic kinase Aurora A regulates microtubule dynamics during neurite extension. Abstract »  
Annalisa M. VanHook
15 September 2009: ec307.
An orphan G protein–coupled receptor is required in Schwann cells to trigger myelination. Abstract »  
L. Bryan Ray
15 September 2009: ec308.
Loss of primary cilia can promote or inhibit cancers dependent on hedgehog signaling. Abstract »  

 

Research Articles

Begoña Diaz, Gidon Shani, Ian Pass, Diana Anderson, Manuela Quintavalle, and Sara A. Courtneidge
15 September 2009: ra53.
Localized production of reactive oxygen species is key for cellular invasiveness and may be involved in a positive feedback loop with proteins that organize their site of production. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Davide Gianni, Begoña Diaz, Nicolas Taulet, Bruce Fowler, Sara A. Courtneidge, and Gary M. Bokoch
15 September 2009: ra54.
Tks proteins, which are Src substrates, control the localized production of reactive oxygen species by Nox. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Helen P. Makarenkova, Matthew P. Hoffman, Andrew Beenken, Anna V. Eliseenkova, Robyn Meech, Cindy Tsau, Vaishali N. Patel, Richard A. Lang, and Moosa Mohammadi
15 September 2009: ra55.
Manipulation of the interaction of a morphogen with the extracellular matrix changes its biological activities by altering its diffusion. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Alissa M. Weaver
15 September 2009: pe56.
Tks proteins organize NADPH oxidase activity and localized production of reactive oxygen species in invasive cells. Abstract »   Full Text »   PDF »  
MacDonald J. Christie and Christophe Mallet
15 September 2009: pe57.
Endocannabinoids generated in the spinal cord can enhance pain responses instead of relieving pain. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882