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Cover Figure

ONLINE COVER This week's issue features two Research Articles (by Diaz et al. and by Gianni et al.) that demonstrate the importance of localized production of reactive oxygen species to cellular invasiveness that contributes to cancer metastasis. The image depicts a macrophage with cellular protrusions known as podosomes. [Image: Begoña Diaz, Burnham Institute for Medical Research]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882