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Editors' Choice

Nancy R. Gough
6 October 2009: ec324.
Treatments to stop smoking contain nicotine at concentrations sufficient to activate TRPA1 channels, which contribute to irritation. Abstract »  
John F. Foley
6 October 2009: ec325.
The Toll-like receptor–dependent release of 25-hydroxycholesterol by macrophages inhibits the production of IgA by B cells. Abstract »  
Elizabeth M. Adler
6 October 2009: ec326.
Tankyrases are previously unknown components of the Wnt signaling pathway that may provide opportunities for therapeutic intervention in Wnt-dependent cancers. Abstract »  
L. Bryan Ray
6 October 2009: ec327.
A signaling pathway in mice mediates the effects of caloric restriction that protect against age-related diseases. Abstract »  
Annalisa VanHook
6 October 2009: ec328.
Negative feedback of JAK-STAT signaling prevents somatic stem cells from outcompeting germline stem cells in the fly testis. Abstract »  
Paula A. Kiberstis
6 October 2009: ec329.
Huge variations in the coats of purebred dogs can be explained by the combinatorial effects of only three genes. Abstract »  



Jean-Paul Vincent and Annalisa M. VanHook
6 October 2009: pc17.
Graded distribution of Wingless is not required for cell proliferation in the fly wing disc. Abstract »   Full Text »   Podcast »  


Research Articles

Luis Alberto Baena-Lopez, Xavier Franch-Marro, and Jean-Paul Vincent
6 October 2009: ra60.
Proliferation of cells in the Drosophila wing does not require a gradient of the morphogen Wingless. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kuo-Wei Lee, Peng-Wen Chen, Chung-An Lu, Shu Chen, Tuan-Hua David Ho, and Su-May Yu
6 October 2009: ra61.
The protein kinase CIPK15 integrates the response to hypoxia with sugar signaling to allow submerged rice seedlings to grow. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Colin Adrain and Seamus J. Martin
6 October 2009: pe62.
Caspase-9 autoprocessing displaces active caspase-9 bound to the apoptosome, thereby limiting proteolytic activity. Abstract »   Full Text »   PDF »  
Katrin Rittinger
6 October 2009: pe63.
DOCK9 uses a unique mechanism to discriminate between GDP- and GTP-bound forms of Cdc42. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882