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Editors' Choice

John F. Foley
13 October 2009: ec330.
The ER stress transducer OASIS is required for BMP2-dependent bone formation by osteoblasts. Abstract »  
L. Bryan Ray
13 October 2009: ec331.
Nuclear JAK2 protein kinase controls gene expression through modification of chromatin. Abstract »  
Elizabeth M. Adler
13 October 2009: ec332.
AMPK plays a role in the increase in permeability of the intestinal epithelial barrier mediated by IFN-{gamma}. Abstract »  
Annalisa M. VanHook
13 October 2009: ec333.
The ability of land plants to sense and respond to cytokinins co-evolved with a mechanism for attenuating cytokinin signaling. Abstract »  
Wei Wong
13 October 2009: ec334.
Reactive oxygen species promote PTEN oxidation, PI3K signaling, and insulin sensitivity in muscle. Abstract »  
Laura M. Zahn
13 October 2009: ec335.
Inflammatory and antiviral programs in dendritic cells are controlled and tuned by a network of regulators. Abstract »  
L. Bryan Ray
13 October 2009: ec336.
Clock-containing neurons in the mouse brain display complex electrophysiology not seen in other brain cells. Abstract »  
Helen Pickersgill
13 October 2009: ec337.
An alternative developmental pathway for vertebrate vasculature segregates a precursor vessel into two separate vessels. Abstract »  



Malcolm A. Meyn, III and Annalisa M. VanHook
13 October 2009: pc18.
Distinct Src kinases regulate the differentiation of embryonic stem cells. Abstract »   Full Text »   Podcast »  


Research Articles

Dimitrios Iliopoulos, Christos Polytarchou, Maria Hatziapostolou, Filippos Kottakis, Ioanna G. Maroulakou, Kevin Struhl, and Philip N. Tsichlis
13 October 2009: ra62.
Akt-dependent induction of a metastatic phenotype may depend on the balance of Akt1 and Akt2. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Caini Liu, Wen Qian, Youcun Qian, Natalia V. Giltiay, Yi Lu, Shadi Swaidani, Saurav Misra, Li Deng, Zhijian J. Chen, and Xiaoxia Li
13 October 2009: ra63.
The adaptor protein Act1 functions as a ubiquitin ligase to mediate interleukin-17 receptor–dependent activation of nuclear factor-{kappa}B. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Malcolm A. Meyn, III and Thomas E. Smithgall
13 October 2009: ra64.
Kinases engineered for inhibitor resistance reveal a unique role for c-Src in embryonic stem cell differentiation. Editor's Summary »   Abstract »   Full Text »   PDF »  



Steven D. Levin
13 October 2009: pe64.
Ubiquitin ligase can be added to the functions of Act1 as it mediates IL-17 signaling. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882