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Cover Figure

ONLINE COVER This week's issue features a Research Article in which kinases engineered to be resistant to inhibitors were used to dissect the roles of individual members of the Src family of kinases in stem cell differentiation and self-renewal. The image shows the structure of the kinase Hck bound to an inhibitor (PDB: 1QCF), which enabled the generation of the inhibitor-resistant kinases. [Image: Christopher Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882