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Editors' Choice

Elizabeth M. Adler
20 October 2009: ec338.
Imatinib protects oocytes from cisplatin-induced apoptosis. Abstract »  
Nancy R. Gough
20 October 2009: ec339.
Evi delivers two synaptic mediators required for formation of the neuromuscular junction: transsynaptic Wnt and postsynaptic dGRIP. Abstract »  
L. Bryan Ray
20 October 2009: ec340.
The enzyme carbonic anhydrase mediates the taste sensation of carbonated drinks. Abstract »  
Paula A. Kiberstis
20 October 2009: ec341.
The protein kinase AMPK couples circadian clocks and metabolism in mammals through effects on a cryptochrome protein. Abstract »  
Peter Stern
20 October 2009: ec342.
A form of subcortical control of cortical information processing is mediated by a synaptic release of serotonin and glutamate. Abstract »  


Editorial Guides

Nancy R. Gough
20 October 2009: eg13.
Multiple approaches are needed to understand brain biology and pathology. Abstract »   Full Text »   PDF »  


Research Articles

Timothy K. Lee, Elissa M. Denny, Jayodita C. Sanghvi, Jahlionais E. Gaston, Nathaniel D. Maynard, Jacob J. Hughey, and Markus W. Covert
20 October 2009: ra65.
A low-concentration paracrine TNF-{alpha} signal contributes to the variability in NF-{kappa}B activation dynamics in the response to lipopolysaccharide. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kohsuke Yamazaki, Jin Gohda, Atsuhiro Kanayama, Yusei Miyamoto, Hiroaki Sakurai, Masahiro Yamamoto, Shizuo Akira, Hidetoshi Hayashi, Bing Su, and Jun-ichiro Inoue
20 October 2009: ra66.
The cooperative activation of NF-{kappa}B by two distinct pathways that diverge at TRAF6 critically contributes to the IL-1–dependent inflammatory response. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Alejandro Berna-Erro, Attila Braun, Robert Kraft, Christoph Kleinschnitz, Michael K. Schuhmann, David Stegner, Thomas Wultsch, Jens Eilers, Sven G. Meuth, Guido Stoll, and Bernhard Nieswandt
20 October 2009: ra67.
Neurons lacking the calcium sensor STIM2 are protected from hypoxia-induced cell death. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Taranjit S. Gujral and Gavin MacBeath
20 October 2009: pe65.
Assessing the state of signaling networks in limited quantity samples may facilitate personalized medical care. Abstract »   Full Text »   PDF »  
Pearl V. Ryder and Victor Faundez
20 October 2009: pe66.
Genetic polymorphisms that affect processes regulated by or participating in endosomal trafficking may increase susceptibility to schizophrenia. Abstract »   Full Text »   PDF »  



Amantha Thathiah and Bart De Strooper
20 October 2009: re8.
β-amyloid may induce neurodegeneration by affecting G protein–coupled receptor signaling. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882