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Editors' Choice

Wei Wong
27 October 2009: ec343.
Certain viruses trigger interferon production through a Toll-like receptor 2–dependent mechanism in inflammatory monocytes. Abstract »  
John F. Foley
27 October 2009: ec344.
Strong stimuli are required to trigger the efficient killing of targets by cytotoxic T cells. Abstract »  
Elizabeth M. Adler
27 October 2009: ec345.
Constitutive internalization of CX3CL1 prevents its proteolytic degradation and may enable its rapid deployment when needed. Abstract »  
Nancy R. Gough
27 October 2009: ec346.
In worms, Eph destabilizes PTEN, which influences either PI3K or MAPK signaling to regulate life span and reproduction, respectively. Abstract »  
Annalisa M. VanHook
27 October 2009: ec347.
Hippo signaling may regulate Yorkie activity through a phosphorylation-independent mechanism. Abstract »  
Paula A. Kiberstis
27 October 2009: ec348.
A mutation that prevents binding of a promising drug lead to its target protein confers resistance in a human brain tumor. Abstract »  
L. Bryan Ray
27 October 2009: ec349.
The ubiquitin ligase Cdc20-APC is required for proper synapse formation in the developing rat brain. Abstract »  
Pamela Hines
27 October 2009: ec350.
Mouse neurons that lack a receptor for inhibitory proteoglycans show improved regeneration. Abstract »  
L. Bryan Ray
27 October 2009: ec351.
Loss of sleep inhibits signaling mechanisms underlying learning and memory. Abstract »  



Myriam Gorospe and Annalisa M. VanHook
27 October 2009: pc19.
Several microRNAs jointly regulate the abundance of the kinase MKK4 during replicative senescence. Abstract »   Full Text »   Podcast »  


Research Articles

Wolfgang Bönigk, Astrid Loogen, Reinhard Seifert, Nachiket Kashikar, Clementine Klemm, Eberhard Krause, Volker Hagen, Elisabeth Kremmer, Timo Strünker, and U. Benjamin Kaupp
27 October 2009: ra68.
The ability of a single molecule of cGMP to activate the K+-selective cyclic nucleotide–gated channel allows sea urchin sperm to find an egg. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Bernard S. Marasa, Subramanya Srikantan, Kiyoshi Masuda, Kotb Abdelmohsen, Yuki Kuwano, Xiaoling Yang, Jennifer L. Martindale, Carrie W. Rinker-Schaeffer, and Myriam Gorospe
27 October 2009: ra69.
Replicative senescence is associated with the decreased abundance of four microRNAs that target the mRNA encoding the kinase MKK4. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Fisun Hamaratoglu, Konrad Basler, and Markus Affolter
27 October 2009: pe67.
A graded distribution of Wingless is not required for growth of the fly wing. Abstract »   Full Text »   PDF »  
Nick R. Leslie
27 October 2009: pe68.
The guanine exchange factor P-REX2 limits the lipid phosphatase activity of PTEN and is a potential oncogene. Abstract »   Full Text »   PDF »  



27 October 2009: er9.
Full Text »   PDF »  


Teaching Resources

Romi L. Burks and Matthew M. Chumchal
27 October 2009: tr3.
The rewards associated with publishing with undergraduate students outweigh the challenges. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882