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Cover Figure

ONLINE COVER This week's issue features a Research Article demonstrating that the transcription factor Rfx4 regionally regulates the formation of primary cilia, cellular structures that are crucial for Sonic hedgehog (Shh) signaling in the developing central nervous system. The image shows the ciliary defects in the telencephalon of a mutant mouse embryo lacking Rfx4 activity. [Image: Amir M. Ashique, Genentech Inc., South San Francisco, CA, USA]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882