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Editors' Choice

John F. Foley
17 November 2009: ec366.
PPAR-{delta} in macrophages is required to efficiently clear apoptotic cells and to prevent autoimmune responses. Abstract »  
Nancy R. Gough
17 November 2009: ec367.
Without STAT3 to limit Rac1 activity, cells move randomly. Abstract »  
Wei Wong
17 November 2009: ec368.
Components of the endoplasmic reticulum quality control are involved in immune responses mediated by the plant pattern recognition receptor EFR. Abstract »  
Elizabeth M. Adler
17 November 2009: ec369.
A stabilized {alpha}-helical peptide penetrates cells to inhibit Notch signaling. Abstract »  
Annalisa M. VanHook
17 November 2009: ec370.
An adult-phase diapause protects the germ line of starved nematodes, and pheromone receptors required for a nematode larval-phase diapause are identified. Abstract »  
Nancy R. Gough
17 November 2009: ec371.
Lysine monomethylation of the transcription factor NF-{kappa}B affects the stability of its interaction with specific gene promoters. Abstract »  
Stella M. Hurtley
17 November 2009: ec372.
Sleep patterns can influence amyloid plaque formation in a mouse model of Alzheimer’s disease. Abstract »  
Kristen Mueller
17 November 2009: ec373.
Suppressor T cells regulate different classes of immune responses through induction of specific transcription factors. Abstract »  
L. Bryan Ray
17 November 2009: ec374.
Activation of an epigenetic switch causes stable cell transformation. Abstract »  


Research Articles

Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, and Jing Chen
17 November 2009: ra73.
Tyrosine phosphorylation of pyruvate kinase M2 gives tumor cells a metabolic advantage. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Marina V. Chuenkova and Mercio PereiraPerrin
17 November 2009: ra74.
A surface protein of the intracellular parasite Trypanosoma cruzi acts both intracellularly and extracellularly to keep infected cells alive. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Chi V. Dang
17 November 2009: pe75.
Aerobic glycolysis in cancer cells is associated with tyrosine phosphorylation of a metabolic enzyme. Abstract »   Full Text »   PDF »  
Kristi L. Norris, Joo-Yong Lee, and Tso-Pang Yao
17 November 2009: pe76.
Proteomic analysis shows protein acetylation to be more prevalent than previously appreciated. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882