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Cover Figure

ONLINE COVER This week's issue features a Research Article describing how tyrosine phosphorylation of pyruvate kinase M2 (PKM2) shifts tumor cell metabolism in a phenomenon known as the Warburg effect and gives them a metabolic advantage. The image (based on PDB 3BJF) shows the crystal structure of PKM2. [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882