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Editors' Choice

Nancy R. Gough
24 November 2009: ec375.
Nod2 functions within T cells to promote differentiation into T helper cells. Abstract »  
John F. Foley
24 November 2009: ec376.
Syk- and MyD88-dependent signaling pathways converge to endow mouse neutrophils with regulatory properties. Abstract »  
L. Bryan Ray
24 November 2009: ec377.
Multiple system-level analyses provide insights into the regulatory events that underlie differentiation of embryonic stem cells. Abstract »  
Wei Wong
24 November 2009: ec378.
PARP-1 promotes the formation of a complex that ultimately leads to NF-{kappa}B activation in the DNA damage response. Abstract »  
Nancy R. Gough
24 November 2009: ec379.
Inverse oscillatory recruitment of two signaling components to interacting Neurospora germling cells prevents cells from self-stimulation. Abstract »  
Stella M. Hurtley
24 November 2009: ec380.
The dysbindin protein is required for the modulation of presynaptic neurotransmitter release in Drosophila. Abstract »  
Stella M. Hurtley
24 November 2009: ec381.
A thioredoxin-like enzyme controls the oxidation state of the bacterial periplasm. Abstract »  



Tony Pawson and Annalisa M. VanHook
24 November 2009: pc21.
Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change. Abstract »   Full Text »   Podcast »  


Research Articles

Chong Chen, Yu Liu, Yang Liu, and Pan Zheng
24 November 2009: ra75.
Rapamycin reverses aging-related declines in hematopoietic stem cell function. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Jing Jin, Xueying Xie, Chen Chen, Jin Gyoon Park, Chris Stark, D. Andrew James, Marina Olhovsky, Rune Linding, Yongyi Mao, and Tony Pawson
24 November 2009: ra76.
Clustering proteins into groups on the basis of their domain compositions provides insight into protein evolution. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Ian F. Smith, Steven M. Wiltgen, Jianwei Shuai, and Ian Parker
24 November 2009: ra77.
Localized calcium signals called Ca2+ puffs arise at preestablished clusters of IP3Rs. Editor's Summary »   Abstract »   Full Text »   PDF »  



David A. Hill and David Artis
24 November 2009: pe77.
The adaptive immune system compensates if innate mechanisms fail to contain microbes in the mammalian intestine. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882