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ONLINE COVER This week's issue features a Research Article describing a proteome-wide clustering method to identify eukaryotic protein domain combinations that correlate with evolutionary change. The analysis was used to make predictions about the role that domain evolution contributes to the evolution of protein function within a molecular environment, as well as to the evolution of molecular environments. The image shows the molecular environment of a protein domain visualized as a heat map on a clustergram. [Image: Xueying Xie and Yongyi Mao, School of Information Technology and Engineering (SITE), University of Ottawa, Ottawa, Ontario, Canada]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882