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Editors' Choice

L. Bryan Ray
1 December 2009: ec382.
Altered phosphorylation of a neurotransmitter receptor leads to specific loss of spatial memory. Abstract »  
John F. Foley
1 December 2009: ec383.
G protein β{gamma} subunits stimulate a Fyn-dependent pathway that reverses thrombin-induced permeability of endothelial cells. Abstract »  
Wei Wong
1 December 2009: ec384.
A protein tyrosine phosphatase binds to cell adhesion proteins through its ectodomain to promote synapse formation. Abstract »  
Elizabeth M. Adler
1 December 2009: ec385.
PEDF promotes Notch signaling in adult neural stem cells by stimulating the p65-dependent nuclear export of the transcriptional corepressor N-CoR. Abstract »  
L. Bryan Ray
1 December 2009: ec386.
A set of comprehensive analyses of the proteome, metabalome, and transcriptome of a relatively simple bacterium reveals insights into signaling, gene regulation, metabolism, and beyond. Abstract »  


Editorial Guides

Michael B. Yaffe
1 December 2009: eg15.
Articles should be judged on their own merit, not the Impact Factor of the journal in which they are published. Abstract »   Full Text »   PDF »  



Alexander Pfeifer and Annalisa M. VanHook
1 December 2009: pc22.
Protein kinase G is required for the differentiation and fat-burning function of brown adipose tissue. Abstract »   Full Text »   Podcast »  


Research Articles

Bodo Haas, Peter Mayer, Katja Jennissen, Daniela Scholz, Mauricio Berriel Diaz, Wilhelm Bloch, Stephan Herzig, Reinhard Fässler, and Alexander Pfeifer
1 December 2009: ra78.
PKG regulates differentiation and thermogenic function in brown adipose tissue. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Nikolaos Patsoukis, Esther M. Lafuente, Paul Meraner, Jin sub Kim, David Dombkowski, Lequn Li, and Vassiliki A. Boussiotis
1 December 2009: ra79.
RIAM, an adaptor protein that regulates integrin signaling, is found to also function in T cell receptor–proximal signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Catherine A. Kraft, Jose Luis Garrido, Luis Leiva-Vega, and Guillermo Romero
1 December 2009: pl4.
The intrinsic fluorescence of tryptophan can be used to quantify the interaction between proteins and lipids. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882