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COVER This week's Focus Issue on signaling in cancer progression features articles on prostate cancer progression, signaling in cancer metastasis, and a Perspective that discusses the possible role of growth factor leakage across tight junctions in contributing to the progression of epithelial cancers.

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882