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Cover Figure

COVER This week features a Perspective on the evolution of nuclear receptors that highlights the diversity of this protein family and the recent cloning of a constitutively active estrogen receptor from Aplysia that does not bind ligand. The cover image illustrates the ligand-binding cavity (green) of the PPARγ nuclear receptor. [Image: John W. R. Schwabe and Sarah A. Teichmann, MRC-Laboratory of Molecular Biology, Cambridge, UK.]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882