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COVER This week features a Review on signaling pathways activated by mechanical stress that promote osteoblast proliferation. The devastating consequences of osteoporosis, a degenerative disease in which bone mass is lost, are most commonly experienced by the elderly, and this Review accompanies a Science Special Issue on aging. The image is of bone. [Image: D.W. Dempster, E. Shane, W. Horbert, R. Lindsay, Helen Hayes Hospital, West Haverstraw, NY.]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882