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Cover Figure

This issue of STKE, which complements the Science Special Issue on Systems-Level Brain Development, contains an Editorial Guide on plastic changes in nervous system function. The picture depicts a model of hippocampal depolarization-induced suppression of inhibition in which the endocannabinoid 2-AG acts as a retrograde messenger. [Image: Christopher Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882