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Cover Figure

COVER This week features a Review on the mechanisms by which inhibitory signals may be propagated through immunoreceptor tyrosine-based activation motifs (ITAMs) to set the activation threshold of immune cells. The image depicts inhibition of FcεRI signal transduction by an FcαRI-FcRγ chimera. [Image: Christopher Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882