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COVER This week's Focus Issue, published to complement the Science Special Issue on cancer therapy, contains an Editorial Guide as well as Perspectives on epidermal growth factor receptor signaling through hypoxia-inducible factors and on regulation of the tumor suppressor p73, which is related to p53, by a nononcogenic alternatively spliced form of H-Ras. The image depicts tumor cells. [Image: Christopher Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882