COVER This week features a Protocol detailing methods for identifying small molecule inhibitors of thyroid receptors. The image shows the crystal structure of the ligand-binding domain (LBD) of thyroid receptor beta (TRβ) in complex with L3, an inhibitor identified using the described methods. The solid representation of TRβ LBD depicts negatively charged residues in red, positively charged residues in blue, hydrophobic residues in gray, and cysteine residues in yellow. L3 is represented as a space-fill model, bound to the AF2 pocket of TRβ. [Image: Alexander Arnold, St. Jude Children's Research Hospital, Memphis, TN]

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