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Cover Figure

COVER This week's Focus Issue, published to complement the Science Special Issue on computational neuroscience, contains an Editorial Guide on excitatory signaling in the brain, as well as a Review that presents a structural model for LTP in the hippocampal CA1 region, a Review on signaling mechanisms involved in limbic epileptogenesis, and a Perspective on D-serine regulation of the NMDA receptor. The image is a laser confocal microscopic image of a coronal section through the hippocampus of a Thy1-green fluorescent protein transgenic mouse. [Image: Yangzhong Huang, Duke University]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882