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COVER This week's Focus Issue, published to complement the Science Special Issue featuring the genome of the California purple sea urchin, contains an Editorial Guide and two Perspectives on signaling during sea urchin development. The image depicts sea urchins in a tidepool. [Image: Charles Hollahan, Santa Barbara Marine Biological]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882