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Cover Figure

COVER This week features a Review on regulation of the inositol 1,4,5-trisphosphate receptor (IP3R) by proteins in the cytoplasm and in the lumen of the endoplasmic reticulum. The image depicts the IP3R releasing calcium into the cytosol. [Image: Christopher Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882