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Perspectives

William O’Gorman and Alexandre Akoulitchev
Sci. STKE 12 December 2006: pe51.
The function of an mRNA extends beyond encoding protein. Abstract »   Full Text »   PDF »  
Jean J. Zhao and Thomas M. Roberts
Sci. STKE 12 December 2006: pe52.
Identifying the roles of different PI3K isoforms may facilitate the use of their inhibitors in cancer therapy. Abstract »   Full Text »   PDF »  

 

Editors' Choice

L. Bryan Ray
Sci. STKE 12 December 2006: tw414.
A new role of a translation initiation factor has it targeting a signaling molecule for degradation. Abstract »  
Nancy R. Gough
Sci. STKE 12 December 2006: tw415.
Secretion of mouse Wnt proteins appears to require acylation of a specific serine with the monounsaturated fatty acid, palmitoleic acid. Abstract »  
L. Bryan Ray
Sci. STKE 12 December 2006: tw416.
Another function for Klotho, a protein implicated in life-span regulation, may be to interact with fibroblast growth factor receptors to adjust the receptor’s specificity. Abstract »  
Nancy R. Gough
Sci. STKE 12 December 2006: tw417.
IRS-1 and IRS-2 play different roles in cancer progression. Abstract »  
Nancy R. Gough
Sci. STKE 12 December 2006: tw418.
NDPK-B stimulates KCa3.1 activity by phosphorylating a C-terminal histidine. Abstract »  
Guy Riddihough
Sci. STKE 12 December 2006: tw419.
When bacteria are starved, a small RNA inhibits transcription by folding to mimic a legitimate promoter target, after which adding nucleotides can restart transcription. Abstract »  
Pamela J. Hines
Sci. STKE 12 December 2006: tw420.
Acetylcholine changes chloride transporter levels, triggering a switch from excitatory to inhibitory signaling in the embryonic chick brain. Abstract »  
Beverly Purnell
Sci. STKE 12 December 2006: tw421.
The segmentation clock, which forms repeated body structures during development, generates many oscillating RNAs that regulate common developmental pathways. Abstract »  
Caroline Ash
Sci. STKE 12 December 2006: tw422.
Activation of a two-component signaling pathway required for Salmonella virulence triggers a burst of transcription that may allow rapid adaptation to new conditions. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882