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Perspectives

Scott P. Heximer and Kendall J. Blumer
Sci. STKE 23 January 2007: pe2.
An unstructured domain allows RGS2 to regulate more than just G proteins. Abstract »   Full Text »   PDF »  
Charles S. Hoffman
Sci. STKE 23 January 2007: pe3.
Proteins that adopt a conformation like that of Gbeta serve various functions in G protein signaling. Abstract »   Full Text »   PDF »  

 

Editors' Choice

Elizabeth M. Adler
Sci. STKE 23 January 2007: tw27.
Neutrophils undergo a reactive oxygen species-triggered death that allows microbial killing by the formation of extracellular traps. Abstract »  
Nancy R. Gough
Sci. STKE 23 January 2007: tw28.
IKK phosphorylation of Bcl10, a mediator in the nuclear factor {kappa}B activation pathway, leads to its degradation and may limit NF-{kappa}B signaling. Abstract »  
L. Bryan Ray
Sci. STKE 23 January 2007: tw29.
Heat-shock cognate protein 70 promotes cell death by stabilizing mRNA encoding the proapoptotic protein Bim. Abstract »  
Nancy R. Gough
Sci. STKE 23 January 2007: tw30.
Intracellular alkalinization caused by DNA damage promotes Bcl-xL deamidation, which releases proapoptotic proteins to trigger cell death. Abstract »  
Elizabeth M. Adler
Sci. STKE 23 January 2007: tw31.
AMPK activation has a neuroprotective effect that involves phosphorylation of the GABAB receptor. Abstract »  
Peter Stern
Sci. STKE 23 January 2007: tw32.
The neural circuit for scratching in turtles unexpectedly shows periodic waves of simultaneous excitatory and inhibitory synaptic activity, rather than the anticipated alternating oscillations. Abstract »  
Barbara R. Jasny
Sci. STKE 23 January 2007: tw33.
Screening of genome databases for bound cysteine-selenocysteine pairs has identified known proteins with redox-active cysteines and predicts previously unknown ones. Abstract »  
Beverly Purnell
Sci. STKE 23 January 2007: tw34.
Furrow formation is initiated during gastrulation when a protein in the outer membrane of epithelial cells binds a cytoskeletal modulator, constricting the outer part of the cells. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882