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Editorial Guides

John F. Foley, Elizabeth M. Adler, and Nancy R. Gough
Sci. STKE 1 May 2007: eg4.
Switching off the immune response is as important as switching it on. Abstract »   Full Text »   PDF »  

 

Perspectives

Chris Hansell and Robert Nibbs
Sci. STKE 1 May 2007: pe18.
Chemokine receptors that mediate the cellular infiltration that causes inflammation can then change hats and help to bring about resolution. Abstract »   Full Text »   PDF »  
Michael Hinz and Claus Scheidereit
Sci. STKE 1 May 2007: pe19.
The scaffold involved in activating NF-{kappa}B also plays a role in terminating the response. Abstract »   Full Text »   PDF »  
Damien Vitour and Eliane F. Meurs
Sci. STKE 1 May 2007: pe20.
Interactions in cis and trans control the activity of CARD-domain proteins involved in regulating immune responses. Abstract »   Full Text »   PDF »  
Elmar Wegener and Daniel Krappmann
Sci. STKE 1 May 2007: pe21.
Signaling complexes using different CARD scaffolds, as well as Bcl10 and Malt1, link receptors in various cells to NF-{kappa}B. Abstract »   Full Text »   PDF »  

 

Editors' Choice

Valda Vinson
Sci. STKE 1 May 2007: tw146.
In maintaining metabolic homeostasis, bacteria respond to genetic disruptions with large changes in metabolites but to environmental disturbance with changes in enzyme levels. Abstract »  
Elizabeth M. Adler
Sci. STKE 1 May 2007: tw147.
The PhoQ protein kinase acts as a pH sensor and is directly activated by acidic pH. Abstract »  
John F. Foley
Sci. STKE 1 May 2007: tw148.
Sphingosine 1-phosphate (S1P), acting through its G protein-coupled receptor S1P1, can substitute for IL-23 in the development of Th17 cells. Abstract »  
Nancy R. Gough
Sci. STKE 1 May 2007: tw149.
An interaction between the endoplasmic reticular protein UNC93B and Toll-like receptors TLR3, TLR7, and TLR9 is important for responding to infection. Abstract »  
L. Bryan Ray
Sci. STKE 1 May 2007: tw150.
Signals initiated by the neurotransmitter serotonin can reverse neuronal responses to axon guidance cues. Abstract »  
Nancy R. Gough
Sci. STKE 1 May 2007: tw151.
The kinase ERK5, acting through the kinase RSK2, activates NF-{kappa}B to promote the expression of genes necessary for progression through mitosis. Abstract »  
Stephen Simpson
Sci. STKE 1 May 2007: tw152.
Deletion of a microRNA sequence in mice impairs their immunity, causing abnormal immune responses and cytokine production, as well as gut and lung inflammation. Abstract »  
Beverly Purnell
Sci. STKE 1 May 2007: tw153.
A microRNA coded within an intron of a myosin gene increases the pathological expression of embryonic myosin after stress. Abstract »  
Stephen Simpson
Sci. STKE 1 May 2007: tw154.
When immune cells process foreign antigen via the endosomes, effector T cells are stimulated, whereas antigen processed by lysosomes activates helper T cells. Abstract »  
Stella M. Hurtley
Sci. STKE 1 May 2007: tw155.
A small regulatory protein is required for recycling of synaptic vesicles during high-frequency neuronal activity, but an independent mechanism maintains basal recycling. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882