Contents

08 May 2007
Vol 2007, Issue 385
  • Contents

    • Perspective

    • Editors' Choice

      • Pulling the Trigger for Apoptosis

        A combination of experiments and mathematical modeling reveals the molecular basis of a switch that determines the life or death of a cell.

      • Plastid Distress Signal

        In a critical regulatory loop for plants, damaged chloroplasts signal their status to the nucleus via a single signaling pathway and its key component, GUN1.

      • Adapting the Adaptor

        An adaptor protein that links antigen activation of immune cells to cell adhesion also acts through a signaling protein complex to induce immune response genes.

      • Synaptic Communication

        Unexpectedly, the main excitatory neurons in the mouse cortex strongly inhibit each other via axon-to-axon activation of inhibitory interneurons.

      • Tau Reduction and Cognitive Decline

        Mice with cognitive deficits resembling Alzheimer's disease show improvement when levels of a protein found in neurofibrillary tangles are transgenically reduced.

About The Cover

Cover image expansion

COVER This week features a Perspective on kinase chaperones in yeast. The image shows Cdc37 and Hsp90 chaperoning a yeast kinase. [Image: Christopher Bickel, AAAS]