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Perspectives

Larry M. Karnitz and Sara J. Felts
Sci. STKE 8 May 2007: pe22.
The chaperone Cdc37 may play a critical role in the chaperoning of most of the protein kinases in yeast. Abstract »   Full Text »   PDF »  

 

Editors' Choice

Nancy R. Gough
Sci. STKE 8 May 2007: tw156.
Bottleneck components that connect signaling pathways are good targets for disrupting signaling. Abstract »  
L. Bryan Ray
Sci. STKE 8 May 2007: tw157.
A combination of experiments and mathematical modeling reveals the molecular basis of a switch that determines the life or death of a cell. Abstract »  
Elizabeth M. Adler
Sci. STKE 8 May 2007: tw158.
Dscam plays a critical role in self-avoidance but not tiling in Drosophila dendritic arborization neurons. Abstract »  
John F. Foley
Sci. STKE 8 May 2007: tw159.
The chewing of a larva on a tobacco plant leaf results in an acute localized signaling cascade that stimulates the defense responses of other leaves. Abstract »  
Pamela J. Hines
Sci. STKE 8 May 2007: tw160.
In a critical regulatory loop for plants, damaged chloroplasts signal their status to the nucleus via a single signaling pathway and its key component, GUN1. Abstract »  
Stephen Simpson
Sci. STKE 8 May 2007: tw161.
An adaptor protein that links antigen activation of immune cells to cell adhesion also acts through a signaling protein complex to induce immune response genes. Abstract »  
Peter Stern
Sci. STKE 8 May 2007: tw162.
Unexpectedly, the main excitatory neurons in the mouse cortex strongly inhibit each other via axon-to-axon activation of inhibitory interneurons. Abstract »  
Stella M. Hurtley
Sci. STKE 8 May 2007: tw163.
Mice with cognitive deficits resembling Alzheimer's disease show improvement when levels of a protein found in neurofibrillary tangles are transgenically reduced. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882