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Editorial Guides

John F. Foley and Nancy R. Gough
Sci. STKE 29 May 2007: eg5.
Technical advances allow analysis of signaling events at the level of single cells and individual molecules. Abstract »   Full Text »   PDF »  



Walter J. Chazin
Sci. STKE 29 May 2007: pe27.
Analysis of EF-hand proteins in complexes with their targets may define the structural basis for functional consequences. Abstract »   Full Text »   PDF »  
Indraneel Ghosh and Mary J. Wirth
Sci. STKE 29 May 2007: pe28.
A new statistical method helps distinguish a protein moving with a purpose from a protein on a random walk. Abstract »   Full Text »   PDF »  
Marian Navratil, Christofer E. Whiting, and Edgar A. Arriaga
Sci. STKE 29 May 2007: pe29.
A microfluidic device counts the number of low abundance proteins in a single cell. Abstract »   Full Text »   PDF »  


Editors' Choice

John F. Foley
Sci. STKE 29 May 2007: tw182.
The arylhydrocarbon receptor (AhR) mediates the cytosolic response of cells to ultraviolet (UVB) irradiation. Abstract »  
Elizabeth M. Adler
Sci. STKE 29 May 2007: tw183.
The transcriptional coactivator PGC-1{alpha} plays a central role in coordinating the circadian cycling with energy metabolism. Abstract »  
Nancy R. Gough
Sci. STKE 29 May 2007: tw184.
NEMO allows infected cells to activate the transcription factors NF-{kappa}B and interferon regulatory factors (IRFs) to mount an efficient antiviral response. Abstract »  
John F. Foley
Sci. STKE 29 May 2007: tw185.
Ligands for Toll-like receptor 2 (TLR2), but not other TLRs, can stimulate the production of interferon-{gamma} by Th1 effector cells. Abstract »  
Nancy R. Gough
Sci. STKE 29 May 2007: tw186.
PDLIM2 is a nuclear E3 ubiquitin ligase that targets a subunit of NF-{kappa}B to PML bodies for degradation. Abstract »  
Nancy R. Gough
Sci. STKE 29 May 2007: tw187.
Inhibition of phospholipase C activity reverses the polarity of phosphatidylinositol-(4,5) phosphate, thereby allowing cells to move away from a chemorepellent. Abstract »  
L. Bryan Ray
Sci. STKE 29 May 2007: tw188.
R-spondins regulate development through a distinct mode of activation of Wnt receptors Abstract »  
L. Bryan Ray
Sci. STKE 29 May 2007: tw189.
A proteomic analysis reveals that DNA damage induces phosphorylation of hundreds of proteins, many of which were not previously associated with this response. Abstract »  
Valda Vinson
Sci. STKE 29 May 2007: tw190.
A repressor protein in Escherichia coli spends about 90% of its time diffusing along DNA, falling off, and trying again if it does not find its specific binding site within 5 milliseconds. Abstract »  
Peter Stern
Sci. STKE 29 May 2007: tw191.
Endocannabinoids can inhibit the growth of axons; mice without one type of cannabinoid receptor have more inhibitory neuronal inputs to cortical areas of the brain. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882