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Perspectives

Deirdre McGarrigle and Xin-Yun Huang
Sci. STKE 26 June 2007: pe35.
G protein-dependent and –independent pathways couple seven-transmembrane receptors to nonreceptor tyrosine kinases. Abstract »   Full Text »   PDF »  

 

Protocols

Vishal Trivedi, Shao Chong Zhang, Walter Stockinger, and Axel Nohturfft
Sci. STKE 26 June 2007: pl3.
This method allows the detection of the interaction between two different vesicular populations. Abstract »   Full Text »   PDF »  

 

Editors' Choice

Beverly A. Purnell
Sci. STKE 26 June 2007: tw222.
In cultured cells, serum regulates the interaction of nuclear actin with a transcriptional coactivator, facilitating its nuclear transport and thus stimulating gene expression. Abstract »  
Elizabeth M. Adler
Sci. STKE 26 June 2007: tw223.
Fluctuations in cytoplasmic pyruvate concentration may directly link energy metabolism to the regulation of calcium influx. Abstract »  
John F. Foley
Sci. STKE 26 June 2007: tw224.
An ATP-binding site in its ankyrin repeat domain modulates the activity of the ion channel TRPV1. Abstract »  
L. Bryan Ray
Sci. STKE 26 June 2007: tw225.
The cathepsin S protease is implicated in generation of chronic pain by releasing a cytokine. Abstract »  
Nancy R. Gough
Sci. STKE 26 June 2007: tw226.
The p75 neurotrophin contributes to tissue scarring by inhibiting plasminogen activity responsible for fibrin degradation. Abstract »  
Elizabeth M. Adler
Sci. STKE 26 June 2007: tw227.
Hyaluronan acts through a TLR4 complex distinct from that mediating the response to LPS to elicit an inflammatory response to sterile injury. Abstract »  
L. Bryan Ray
Sci. STKE 26 June 2007: tw228.
A large genetic screen and automated characterization of cell morphology allowed mapping of the pathways controlling cell adhesion and membrane protrusion and tension. Abstract »  
Barbara R. Jasny
Sci. STKE 26 June 2007: tw229.
The genome of the mosquito that carries dengue and yellow fever consists of almost 50 percent transposable elements and more than 15,000 protein-coding genes. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882