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Perspectives

Qian Qi and Avery August
Sci. STKE 24 July 2007: pe39.
The adaptor protein SLP-76 serves as more than a neutral adaptor during T cell activation. Abstract »   Full Text »   PDF »  
Peter J. M. Van Haastert and Douwe M. Veltman
Sci. STKE 24 July 2007: pe40.
Multiple signaling pathways promote cell movement through a chemoattractive gradient. Abstract »   Full Text »   PDF »  

 

Editors' Choice

John F. Foley
Sci. STKE 24 July 2007: tw258.
Tumor growth of oncogenic Ras-expressing cells is dependent on interleukin-6. Abstract »  
Nancy R. Gough
Sci. STKE 24 July 2007: tw259.
The activity of calpain appears to control whether acetylcholine receptors cluster or disperse. Abstract »  
Elizabeth M. Adler
Sci. STKE 24 July 2007: tw260.
Otopetrin 1, a multitransmembrane protein critical to otoconia formation, modulates the Ca2+ response to ATP. Abstract »  
L. Bryan Ray
Sci. STKE 24 July 2007: tw261.
Signaling on cilia occurs when a soluble ligand binds to a receptor and relieves an inhibitory interaction, allowing regulation of development and other processes. Abstract »  
Nancy R. Gough
Sci. STKE 24 July 2007: tw262.
During Drosophila border cell migration, exchange of the leading cell allows collective guidance of the cluster. Abstract »  
L. Bryan Ray
Sci. STKE 24 July 2007: tw263.
Loss of Wnt signaling is implicated in cell senescence. Abstract »  
Beverly A. Purnell
Sci. STKE 24 July 2007: tw264.
Mice engineered with a brain-specific decrease in insulin-like signaling have their life spans extended as much as those in mice with a similar defect throughout their bodies. Abstract »  
Valda J. Vinson
Sci. STKE 24 July 2007: tw265.
The variations in binding selectivity of a common protein binding domain are evenly distributed in selectivity space, rather than arranged in discrete clusters as had been assumed. Abstract »  
Stephen J. Simpson
Sci. STKE 24 July 2007: tw266.
Cytomegalovirus aids its own survival by encoding a microRNA that inhibits, in the infected host cell, translation of a ligand that would normally trigger antiviral responses. Abstract »  
Laura M. Zahn
Sci. STKE 24 July 2007: tw267.
Honey bee hives with genetically diverse members stored more food and thus survived better than those with members from a single male founder. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882