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Cover Figure

COVER This week's Focus Issue, published to complement the Science Special Issue on Challenges in Immunology, contains an Editorial Guide, a Review, and two Perspectives that discuss signals that affect the fate and responsiveness of T lymphocytes. The image depicts the activation of a naïve CD4+ T lymphocyte by a dendritic cell and its subsequent expansion and differentiation into a long-lived memory cell. [Image: Preston Huey, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882