14 August 2007
Vol 2007, Issue 399
  • Contents

    • Perspective

    • Editors' Choice

      • Feeling the Itch

        The gastrin-releasing peptide receptor mediates a central pathway for itch sensation.

      • All That JAZ

        Jasmonate signaling stimulates the degradation of JAZ-family transcriptional repressors, enabling the transcriptional activation of target genes.

      • IKKβ Promotes Tumorigenesis

        By inactivating the tuberous sclerosis complex (TSC), this kinase downstream of inflammatory cytokines stimulates the mTOR pathway and angiogenesis.

      • Calcium and Chemotaxis

        PLC-β-mediated intracellular Ca2+ flux contributes to SDF-1α-induced T cell chemotaxis.

      • Making IL-33 Less Complex

        Two studies identify the second subunit of the IL-33 receptor and demonstrate the role of IL-33 in mast cells.

      • Wnt, the Fountain of Youth?

        In older mice, overexpression of a signaling pathway may inhibit muscle regeneration by accelerating stem cell senescence while decreasing their proliferation.

      • High-Salt Survival Tactics

        Molecular dynamics simulations of a Na+/H+ antiporter allow the proposal of an atomically detailed model for the mechanism of ion transport, pH regulation, and cation selectivity.

    • Connections Map Overview

      • TGF-β Signaling in Development

        This pathway highlights the role of the TGF-β signaling pathway in key aspects of mammalian development.

About The Cover

Cover image expansion

COVER This week features a Perspective on how nicotine modulates synaptic plasticity in the prefrontal cortex. The image depicts a ball-and-stick model of nicotine.