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Perspectives

Yuval Dor and Ben Z. Stanger
Sci. STKE 27 November 2007: pe66.
Methods that enhance the proliferative and functional capacity of terminally differentiated cells may offer the greatest promise for creating tissues for human therapy. Abstract »   Full Text »   PDF »  
Lawrence A. Quilliam
Sci. STKE 27 November 2007: pe67.
Interplay between the guanine nucleotide exchange factors SOS and RasGRP1 regulates Ras activation. Abstract »   Full Text »   PDF »  

 

Protocols

Anne C. von Philipsborn, Susanne Lang, Zhongxiang Jiang, Friedrich Bonhoeffer, and Martin Bastmeyer
Sci. STKE 27 November 2007: pl6.
Cellular responses to a defined microscopic pattern of a protein can be studied in a controlled in vitro environment. Abstract »   Full Text »   PDF »  

 

Editors' Choice

John F. Foley
Sci. STKE 27 November 2007: tw430.
The hormone leptin, which suppresses appetite, protects dopaminergic neurons from neurotoxin-induced apoptosis. Abstract »  
Elizabeth M. Adler
Sci. STKE 27 November 2007: tw431.
Regulatory T cells may inhibit the immune response by depriving effector T cells of cytokines and thereby eliciting their apoptotic death. Abstract »  
John F. Foley
Sci. STKE 27 November 2007: tw432.
Hypoxic preconditioning occurs in nematodes and is dependent on the Apaf-1 homolog, CED-4. Abstract »  
Beverly A. Purnell
Sci. STKE 27 November 2007: tw433.
Transcription factors that modulate light responses in plants have been co-opted from an ancestral transposon, suggesting that mobile elements are a driving force in evolution. Abstract »  
Valda Vinson and Nancy Gough
Sci. STKE 27 November 2007: tw434.
The 2.4 Å structure of the human β2-adrenergic receptor displays an architecture and helical orientation distinct from that of rhodopsin, the prototypical member of this family. Abstract »  
L. Bryan Ray
Sci. STKE 27 November 2007: tw435.
Pancreatic β cells maintain high amounts of the signaling molecule inositol pyrophosphate to help ensure ready release of insulin in response to metabolic demands. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882