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Perspectives

Etty N. Benveniste and Hongwei Qin
Sci. STKE 11 December 2007: pe70.
Type I interferons reduce inflammation by inhibiting proinflammatory gene expression and inducing immunosuppressive protein production. Abstract »   Full Text »   PDF »  
Stefanie Kaech, Gary Banker, and Phillip Stork
Sci. STKE 11 December 2007: pe71.
The small GTPase Rit promotes axonal growth while inhibiting dendritic growth. Abstract »   Full Text »   PDF »  
Philip W. Majerus
Sci. STKE 11 December 2007: pe72.
IP7 is involved in responding to low-phosphate conditions in yeast, but the physiological relevance of protein pyrophosphorylation remains less clear. Abstract »   Full Text »   PDF »  

 

Editors' Choice

John F. Foley
Sci. STKE 11 December 2007: tw445.
Squamous carcinoma cells follow tracks laid down by cancer-associated fibroblasts that invade and remodel a matrix. Abstract »  
Nancy R. Gough
Sci. STKE 11 December 2007: tw446.
Proper orientation of the spindle parallel to the substratum in cultured adherent nonpolarized cells requires phosphatidylinositol 3,4,5-trisphosphate. Abstract »  
Nancy R. Gough
Sci. STKE 11 December 2007: tw447.
IGFBP1 binds BAK at the mitochondria, blocking p53 from triggering BAK oligomerization and inducing apoptosis. Abstract »  
John F. Foley
Sci. STKE 11 December 2007: tw448.
Proteasome inhibitor-induced cell death in melanoma cells is mediated by c-Myc. Abstract »  
L. Bryan Ray
Sci. STKE 11 December 2007: tw449.
A mechanism is revealed for the effects of noradrenaline on pain sensation in the brain. Abstract »  
Peter Stern
Sci. STKE 11 December 2007: tw450.
A gene variant that leads to fewer dopamine receptors also prevents people from learning from their mistakes and inhibits feedback to a brain area that registers bad outcomes. Abstract »  
Peter Stern
Sci. STKE 11 December 2007: tw451.
A psychosis-inducing drug activates a brain inflammatory enzyme system that produces superoxide, which decreases activity in certain GABA-containing interneurons. Abstract »  
L. Bryan Ray
Sci. STKE 11 December 2007: tw452.
Interferon secretion in response to viral infection is reduced by an enzyme that removes ubiquitin chains from proteins, an effect that could inhibit autoimmune disease. Abstract »  
Valda Vinson
Sci. STKE 11 December 2007: tw453.
Open and closed structures of an intramembrane protease reveal that it has six segments spanning the membrane and that its zinc active site is accessible only when it is open. Abstract »  
Laura M. Zahn
Sci. STKE 11 December 2007: tw454.
Bt toxin, a natural insecticide engineered into plants, can be modified to overcome insect resistance by forming damaging pores in pests independently of its normal receptor. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882