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Perspectives

Marc Dalod
Sci. STKE 18 December 2007: pe73.
The adaptor protein SARM1, a member of the MyD88 family, mediates neuronal death and modulates immune responses. Abstract »   Full Text »   PDF »  

 

Protocols

Anja Nohe and Nils O. Petersen
Sci. STKE 18 December 2007: pl7.
The family of Image Correlation Spectroscopy techniques can be used to measure the aggregation, clustering, and dynamics of proteins in the plasma membrane. Abstract »   Full Text »   PDF »  
Ulla Schwertassek, Lars Weingarten, and Tobias P. Dick
Sci. STKE 18 December 2007: pl8.
This procedure allows the assessment of the oxidoreductase reactivity of cell-surface proteins within their native environment. Abstract »   Full Text »   PDF »  

 

Editors' Choice

John F. Foley
Sci. STKE 18 December 2007: tw455.
The inositol kinase Ipk1, which synthesizes IP6, regulates both the length and motion of cilia. Abstract »  
Elizabeth M. Adler
Sci. STKE 18 December 2007: tw456.
Lipid binding by the Par-3 PDZ2 domain is critical to its role in epithelial polarization. Abstract »  
Valda Vinson
Sci. STKE 18 December 2007: tw457.
Mutations commonly associated with cancer result in disrupted interactions between the domains of a growth-related lipid kinase and alter its regulation or activity. Abstract »  
Nancy R. Gough
Sci. STKE 18 December 2007: tw458.
TAM receptor tyrosine kinases serve in a negative feedback loop to terminate Toll-like receptor signaling in dendritic cells. Abstract »  
L. Bryan Ray
Sci. STKE 18 December 2007: tw459.
The histone acetylase CLOCK contributes to both positive and negative feedback loops in regulation of circadian gene transcription. Abstract »  
L. Bryan Ray and Pamela J. Hines
Sci. STKE 18 December 2007: tw460.
Plants and animals adjust responses to their environments through small molecules, including metabolites, that interact with their circadian clocks. Abstract »  
Nancy R. Gough
Sci. STKE 18 December 2007: tw461.
Excess elastase in lungs of patients with cystic fibrosis or obstructive lung disease appears to cause cleavage of neutrophil CXCR1 receptors, impairing bacterial killing. Abstract »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882