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Editors' Choice

Nancy R. Gough
5 January 2010: ec1.
A screen of irreversible inhibitors targeting the drug-resistant mutant form of the EGFR yields new candidates for treatment of non–small-cell lung cancer. Abstract »  
Wei Wong
5 January 2010: ec2.
The activity of the Wnt receptor LRP6 is regulated in a cell cycle–dependent manner. Abstract »  
Nancy R. Gough
5 January 2010: ec3.
By interacting with a particular set of neurexin splice variants, leucine-rich repeat transmembrane protein 2 contributes to the formation of excitatory synapses. Abstract »  
Peter R. Stern
5 January 2010: ec4.
Potassium channel enrichment in the dendrites of hippocampal basket cells defines a mechanism of neural network function. Abstract »  
L. Bryan Ray
5 January 2010: ec5.
Mammalian target of rapamycin (mTOR) protein is proposed to act at the mitochondrial membrane to control metabolism. Abstract »  
Helen Pickersgill
5 January 2010: ec6.
A posttranslational sugar modification required to prevent certain dystrophies is identified and characterized. Abstract »  

 

Editorial Guides

Elizabeth M. Adler
5 January 2010: eg1.
This year's signaling breakthroughs emphasize the importance of looking beyond linear signaling pathways. Abstract »   Full Text »   PDF »  

 

Research Articles

Margitta Elvers, David Stegner, Ina Hagedorn, Christoph Kleinschnitz, Attila Braun, Marijke E. J. Kuijpers, Michael Boesl, Qin Chen, Johan W. M. Heemskerk, Guido Stoll, Michael A. Frohman, and Bernhard Nieswandt
5 January 2010: ra1.
In the absence of PLD1, platelets do not form stable aggregates under high shear conditions. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Podcasts

Michael B. Yaffe and Annalisa M. VanHook
5 January 2010: pc1.
Chief Scientific Editor Michael Yaffe reviews the year in Science Signaling. Abstract »   Full Text »   Podcast »  

 

Perspectives

Antonella Riccio
5 January 2010: pe1.
Extracellular stimuli can elicit alterations in gene transcription through regulation of histone deacetylases by sphingosine-1-phosphate. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882