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Editors' Choice

Annalisa M. VanHook
12 January 2010: ec7.
BMP signaling plays a role in energy homeostasis. Abstract »  
John F. Foley
12 January 2010: ec8.
The increased abundance of the lipase MAGL and of signaling lipids in aggressive tumor cells contributes to their malignancy. Abstract »  
Wei Wong
12 January 2010: ec9.
Chronic active B cell receptor signaling promotes cell survival in some types of diffuse large B cell lymphomas. Abstract »  
Nancy R. Gough
12 January 2010: ec10.
Histones are removed and then replaced at the promoter of the gene encoding endothelial nitric oxide synthase in response to hypoxia. Abstract »  
Guy Riddihough
12 January 2010: ec11.
Phosphorylation of the chromatin protein histone H2A plays a critical role in chromosome segregation during cell division. Abstract »  
Peter R. Stern
12 January 2010: ec12.
Cocaine suppression of histone methylation in the nucleus accumbens mediates the drug’s ability to enhance reward. Abstract »  
Nancy R. Gough
12 January 2010: ec13.
The kinases ATM and ATR associate with synaptic vesicle proteins and influence synaptic plasticity. Abstract »  
Elizabeth M. Adler
12 January 2010: ec14.
Bacterial invasion elicits autophagy through Nod1 and Nod2 independently of RIP2 and the NF-{kappa}B signaling pathway. Abstract »  
Pamela M. Hines
12 January 2010: ec15.
Intestinal stem cell progenitors use Notch signaling to specify a niche cell that remains undifferentiated until metamorphosis. Abstract »  
Paula A. Kiberstis
12 January 2010: ec16.
Sequence variations in an adrenergic receptor gene cause reduced insulin secretion and contribute to type 2 diabetes. Abstract »  
L. Bryan Ray
12 January 2010: ec17.
Signaling by the secreted morphogen wingless controls deposition of a myosin II–containing barrier that prevents cell mixing at segmental boundaries of the fly embryo. Abstract »  


Research Articles

Zihao Wang, Namrata D. Udeshi, Chad Slawson, Philip D. Compton, Kaoru Sakabe, Win D. Cheung, Jeffrey Shabanowitz, Donald F. Hunt, and Gerald W. Hart
12 January 2010: ra2.
Protein O-GlcNAcylation regulates cell division. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Jesper V. Olsen, Michiel Vermeulen, Anna Santamaria, Chanchal Kumar, Martin L. Miller, Lars J. Jensen, Florian Gnad, Jürgen Cox, Thomas S. Jensen, Erich A. Nigg, Søren Brunak, and Matthias Mann
12 January 2010: ra3.
Protein phosphorylation during the cell cycle may be an all-or-none process in many instances. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Paul S. Amieux and G. Stanley McKnight
12 January 2010: pe2.
cGMP-mediated signaling pathways are required for the differentiation and function of brown adipocytes. Abstract »   Full Text »   PDF »  



Ross Corriden and Paul A. Insel
12 January 2010: re1.
Responses to ATP play an important role in regulating the signaling and function of a diverse array of cells and tissues. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882