ONLINE COVER This week, Science Signaling publishes a Focus Issue that complements the Science Special Issue on Innate Immunity. Topics covered include the responses of host cells to factors from invading organisms, the processing and signaling of the proinflammatory cytokine interleukin-1β, and the regulation of dendritic cells during the adaptive immune response. The image depicts processes from a dendritic cell (in blue) binding to bacteria. The recognition of microbial products through external and internal receptors by dendritic cells triggers immune responses. [Credit: Chris Bickel, AAAS]

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