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Editors' Choice

Elizabeth M. Adler
19 January 2010: ec18.
CXCR7 mediates ligand-induced β-arrestin signaling in the absence of G protein signaling. Abstract »  
L. Bryan Ray
19 January 2010: ec19.
Cell adhesion mediated by integrins is coupled to intracellular signaling by direct binding to G protein. Abstract »  
L. Bryan Ray
19 January 2010: ec20.
A Wnt ligand activates one pathway and inhibits another emanating from the same receptor. Abstract »  
John F. Foley
19 January 2010: ec21.
The pheromone cVA promotes aggression in Drosophila through olfactory sensory neurons that express the receptor Or67d. Abstract »  
Annalisa M. VanHook
19 January 2010: ec22.
A large-scale screen of neuroactive compounds identifies pathways that may play a role in regulating rest-wake activity. Abstract »  
Wei Wong
19 January 2010: ec23.
Exogenous exposure to the gas hydrogen sulfide activates HIF-1 in Caenorhabditis elegans. Abstract »  
Nancy R. Gough
19 January 2010: ec24.
By inhibiting the production of farnesyl pyrophosphate, statins may promote epithelial wound healing. Abstract »  
Wei Wong
19 January 2010: ec25.
A secreted factor promotes the development of stomata in leaf epidermis. Abstract »  


Editorial Guides

John F. Foley and Nancy R. Gough
19 January 2010: eg2.
Host defense mechanisms are modulated by host-derived and pathogen-derived factors. Abstract »   Full Text »   PDF »  


Connections Map Overviews

Axel Weber, Peter Wasiliew, and Michael Kracht
19 January 2010: cm1.
IL-1{alpha} and IL-1β orchestrate the proinflammatory response by multiple tightly controlled mechanisms. Abstract »   Full Text »   PDF »   Pathway »  
Axel Weber, Peter Wasiliew, and Michael Kracht
19 January 2010: cm2.
The NALP3 inflammasome pathway controls processing and release of interleukin-1β. Abstract »   Full Text »   PDF »   Pathway »  


Research Articles

Kazuhiko Arima, Norihiko Watanabe, Shino Hanabuchi, Mikyoung Chang, Shao-Cong Sun, and Yong-Jun Liu
19 January 2010: ra4.
The cytokine TSLP triggers distinct signals in dendritic cells that program a T helper 2 (TH2)–type response. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Christophe Préhaud, Nicolas Wolff, Elouan Terrien, Mireille Lafage, Françoise Mégret, Nicolas Babault, Florence Cordier, Gene S. Tan, Elodie Maitrepierre, Pauline Ménager, Damien Chopy, Sylviane Hoos, Patrick England, Muriel Delepierre, Matthias J. Schnell, Henri Buc, and Monique Lafon
19 January 2010: ra5.
Survival of rabies virus–infected neurons depends on a single amino acid in the PDZ-binding site of a viral protein. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Shelly M. Wuerzberger-Davis and Shigeki Miyamoto
19 January 2010: pe3.
IL-1β-dependent activation of NF-{kappa}B occurs in two distinct stages. Abstract »   Full Text »   PDF »  



José Luis Rodríguez-Fernández, Lorena Riol-Blanco, and Cristina Delgado-Martín
19 January 2010: re2.
The immunological synapse organizes signaling responses in dendritic cells as well as in T cells. Gloss »   Abstract »   Full Text »   PDF »  
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