Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Cover Figure

ONLINE COVER This week's issue features a Research Article that demonstrates how insulin-like growth factor 1 (IGF-1) stimulates the modification of its receptor (IGF-1R) by small ubiquitin-like modifier (SUMO) proteins. SUMOylated IGF-1R then translocates to the nucleus, where it acts as a transcriptional regulator. The image shows the structure of human IGF-1R (based on PDB 1K3A), with the three critical lysine residues that are targeted for SUMOylation highlighted in red. [Image: Chris Bickel, AAAS]

[Table of Contents]


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882