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Cover Figure

ONLINE COVER This week's issue features a Research Article that demonstrates how insulin-like growth factor 1 (IGF-1) stimulates the modification of its receptor (IGF-1R) by small ubiquitin-like modifier (SUMO) proteins. SUMOylated IGF-1R then translocates to the nucleus, where it acts as a transcriptional regulator. The image shows the structure of human IGF-1R (based on PDB 1K3A), with the three critical lysine residues that are targeted for SUMOylation highlighted in red. [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882