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Editors' Choice

John F. Foley
9 February 2010: ec45.
Transgenic mice that coexpress binding-defective and signaling-defective forms of luteinizing hormone receptor respond normally to its ligand. Abstract »  
Nancy R. Gough
9 February 2010: ec46.
In the budding yeast Kluyveromyces lactis, the β subunit of the G protein can function without the {gamma} subunit in the mating response. Abstract »  
Wei Wong
9 February 2010: ec47.
A kinase with a role in the detection of RNA-based viruses also responds to metabolic stress. Abstract »  
Annalisa M. VanHook
9 February 2010: ec48.
BMPs can induce redeployment of the developmental program to restore regenerative potential in the mouse digit tip. Abstract »  
Elizabeth M. Adler
9 February 2010: ec49.
Parkin-dependent ubiquitylation of VDAC1 links PINK1 activity to autophagy of dysfunctional mitochondria. Abstract »  


Research Articles

Hsu-Ping Kuo, Dung-Fang Lee, Chun-Te Chen, Mo Liu, Chao-Kai Chou, Hong-Jen Lee, Yi Du, Xiaoming Xie, Yongkun Wei, Weiya Xia, Zhang Weihua, Jer-Yen Yang, Chia-Jui Yen, Tzu-Hsuan Huang, Minjia Tan, Gang Xing, Yingming Zhao, Chien-Hsing Lin, Shih-Feng Tsai, Isaiah J. Fidler, and Mien-Chie Hung
9 February 2010: ra9.
Acetylation by ARD1 of an inhibitor of mammalian target of rapamycin may inhibit cancer growth. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Bita Sehat, Ali Tofigh, Yingbo Lin, Eric Trocmé, Ulrika Liljedahl, Jens Lagergren, and Olle Larsson
9 February 2010: ra10.
Attachment of SUMO lets insulin-like growth factor receptors act as transcriptional regulators in the nucleus. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Michael J. Garabedian and Susan K. Logan
9 February 2010: pe5.
By mimicking a DNA response element, a noncoding RNA inhibits glucocorticoid receptor activity. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882