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Editors' Choice

Elizabeth M. Adler
16 February 2010: ec50.
A sarcolemmal fraction of the {alpha}1S subunit may act as a sensor to couple muscle activity with muscle growth. Abstract »  
L. Bryan Ray
16 February 2010: ec51.
Depending on the activating signal, activation of phospholipase C–β2 in the plasma membrane can be localized or dispersed. Abstract »  
Nancy R. Gough
16 February 2010: ec52.
The E3 ubiquitin ligase Nedd4 contributes to both dendritic and axonal branching. Abstract »  
Wei Wong
16 February 2010: ec53.
A deubiquitinase promotes nuclear localization of p53 in response to DNA damage. Abstract »  
John F. Foley
16 February 2010: ec54.
The neurotransmitter GABA acts in the immune system to ameliorate symptoms in a mouse model of multiple sclerosis. Abstract »  
Nancy R. Gough
16 February 2010: ec55.
Excessive mTOR activity impairs ephrin-mediated growth cone collapse. Abstract »  
Guy Riddihough
16 February 2010: ec56.
A bacterial signaling molecule induces the dimerization and activation of a biofilm-promoting transcription factor. Abstract »  


Connections Map Overviews

Aurélie Gfeller, Lucie Dubugnon, Robin Liechti, and Edward E. Farmer
16 February 2010: cm3.
Jasmonates are potent physiological and developmental regulators synthesized from fatty acid precursors. Abstract »   Full Text »   PDF »   Structures of Jasmonate and its Precursors »  Biosynthesis Enzymes »   Pathway »  
Aurélie Gfeller, Robin Liechti, and Edward E. Farmer
16 February 2010: cm4.
Jasmonates regulate various aspects of physiology and development in Arabidopsis thaliana. Abstract »   Full Text »   PDF »   Pathway »  



George Hajishengallis and Annalisa M. VanHook
16 February 2010: pc4.
The pathogen Porphyromonas gingivalis evades the innate immune system by initiating signaling crosstalk. Abstract »   Full Text »   Podcast »  


Research Articles

Min Wang, Jennifer L. Krauss, Hisanori Domon, Kavita B. Hosur, Shuang Liang, Paola Magotti, Martha Triantafilou, Kathy Triantafilou, John D. Lambris, and George Hajishengallis
16 February 2010: ra11.
Pathogen-instigated crosstalk between the complement C5a receptor and Toll-like receptor 2 disables innate immune function. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Janine Mok, Philip M. Kim, Hugo Y. K. Lam, Stacy Piccirillo, Xiuqiong Zhou, Grace R. Jeschke, Douglas L. Sheridan, Sirlester A. Parker, Ved Desai, Miri Jwa, Elisabetta Cameroni, Hengyao Niu, Matthew Good, Attila Remenyi, Jia-Lin Nianhan Ma, Yi-Jun Sheu, Holly E. Sassi, Richelle Sopko, Clarence S. M. Chan, Claudio De Virgilio, Nancy M. Hollingsworth, Wendell A. Lim, David F. Stern, Bruce Stillman, Brenda J. Andrews, Mark B. Gerstein, Michael Snyder, and Benjamin E. Turk
16 February 2010: ra12.
A high-throughput peptide array approach reveals insight into kinase substrates and specificity. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882