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Editors' Choice

Wei Wong
2 March 2010: ec65.
Tyrosine phosphorylation of an H2O2-detoxifying enzyme enables localized accumulation of H2O2 involved in signal transduction. Abstract »  
Nancy R. Gough
2 March 2010: ec66.
Glutamate-dependent organization of the visual input requires molecules traditionally associated with immune responses. Abstract »  
Wei Wong
2 March 2010: ec67.
Kibra interacts with Expanded and Merlin in the Hippo pathway to control organ size. Abstract »  
Pamela J. Hines
2 March 2010: ec68.
Products encoded by the leguminous plant Medicago direct the differentiation of the bacterial partner in symbiosis. Abstract »  
Stella M. Hurtley
2 March 2010: ec69.
A bacterial toxin targets and modifies the actin cytoskeleton in insect larvae. Abstract »  
L. Bryan Ray
2 March 2010: ec70.
The multifunctional A20 protein can act in diverse ways to limit receptor-induced inflammatory signaling. Abstract »  

 

Research Articles

Martha Stapels, Chelsea Piper, Tao Yang, Minghua Li, Cheri Stowell, Zhi-gang Xiong, Julie Saugstad, Roger P. Simon, Scott Geromanos, James Langridge, Jing-quan Lan, and An Zhou
2 March 2010: ra15.
Polycomb group proteins protect neurons from injury through a mechanism involving decreased potassium channel function. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Ross Kinstrie, Nathan Luebbering, Diego Miranda-Saavedra, Gary Sibbet, Jingfen Han, Pamela A. Lochhead, and Vaughn Cleghon
2 March 2010: ra16.
An N-terminal region of a dual-specificity kinase temporarily enables it to phosphorylate a tyrosine rather than a serine or a threonine residue. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Qilu Ye, Scott W. Crawley, Yidai Yang, Graham P. Côté, and Zongchao Jia
2 March 2010: ra17.
Structural analysis identifies features of atypical serine-threonine kinases that may account for their different activities relative to those of conventional kinases. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Thanashan Rajakulendran and Frank Sicheri
2 March 2010: pe8.
A kinase becomes activated when it binds as the "substrate" of a pseudokinase. Abstract »   Full Text »   PDF »  
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