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ONLINE COVER This week's issue features a Research Article that describes the crystal structure of the α-kinase domain (A-CAT) of Dictyostelium myosin II heavy chain kinase A (MHCK A), a member of the atypical α-kinase family of serine and threonine protein kinases. Details from this structure reveal features that distinguish α-kinases from conventional protein kinases. The image shows the distribution of electrostatic potential on the surface of A-CAT. [Image: Graham P. Côté, Department of Biochemistry, Queen's University, Kingston, Ontario, Canada]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882