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Editors' Choice

Nancy R. Gough
9 March 2010: ec71.
miR-328 promotes the production of a protein by competing with its transcript for an inhibitory RNA binding protein. Abstract »  
Wei Wong
9 March 2010: ec72.
Stimulation by parathyroid hormone promotes endocytosis of its receptor in complex with the TGF-β receptor. Abstract »  
Stella M. Hurtley
9 March 2010: ec73.
An intracellular membrane-sorting machinery participates in cellular corpse clearance. Abstract »  
Elizabeth M. Adler
9 March 2010: ec74.
Circadian oscillators in gustatory receptor neurons mediate rhythms in taste sensitivity and modulate feeding behavior in Drosophila. Abstract »  
L. Bryan Ray
9 March 2010: ec75.
Sestrin proteins protect fruit flies from the tissue degeneration and disruption of metabolic homeostasis that accompany aging. Abstract »  
Peter R. Stern
9 March 2010: ec76.
Previous reports of glial cell activity may reflect the pharmacological approaches used and not endogenous activity. Abstract »  


Research Articles

Pamela R. Westmark, Cara J. Westmark, SuQing Wang, Jonathan Levenson, Kenneth J. O’Riordan, Corinna Burger, and James S. Malter
9 March 2010: ra18.
A feedback loop involving Pin1, protein synthesis, and protein kinase M {zeta} regulates a persistent form of synaptic plasticity. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Todd Charlton Sacktor
9 March 2010: pe9.
Memory storage requires the inhibition of a peptidyl-prolyl isomerase to enable synthesis of the kinase PKM{zeta}. Abstract »   Full Text »   PDF »  



Gerasimos P. Sykiotis and Dirk Bohmann
9 March 2010: re3.
The oxidative stress response is an attractive target for treating human diseases and extending the healthy life span. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882