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ONLINE COVER This week's issue features a Research Article describing a mathematical approach to narrow down the possible pathways that a cell uses to respond to a stimulus. With this approach, the authors showed that two isoforms of the kinase Raf contribute to activation of extracellular signal–regulated kinase by epidermal growth factor. [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882