<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" level="2" version="1">
  <model id="Model_4" name="Model 4: Two branches plus receptor degradation">
    <listOfCompartments>
      <compartment id="cell" name="cell" size="1"/>
    </listOfCompartments>
    <listOfSpecies>
      <species id="EGF" name="EGF" compartment="cell" initialAmount="0"/>
      <species id="boundEGFR" name="boundEGFR" compartment="cell" initialAmount="0"/>
      <species id="unboundEGFR" name="unboundEGFR" compartment="cell" initialAmount="500"/>
      <species id="activeSos" name="activeSos" compartment="cell" initialAmount="0"/>
      <species id="inactiveSos" name="inactiveSos" compartment="cell" initialAmount="1200"/>
      <species id="activeRas" name="activeRas" compartment="cell" initialAmount="0"/>
      <species id="inactiveRas" name="inactiveRas" compartment="cell" initialAmount="1200"/>
      <species id="cRaf" name="cRaf" compartment="cell" initialAmount="1500"/>
      <species id="cRafPP" name="cRafPP" compartment="cell" initialAmount="0"/>
      <species id="MEK" name="MEK" compartment="cell" initialAmount="3000"/>
      <species id="MEKPP" name="MEKPP" compartment="cell" initialAmount="0"/>
      <species id="ERK" name="ERK" compartment="cell" initialAmount="10000"/>
      <species id="ERKPP" name="ERKPP" compartment="cell" initialAmount="0"/>
      <species id="removedSos" name="removedSos" compartment="cell" initialAmount="0"/>
      <species id="PKA" name="PKA" compartment="cell" initialAmount="0"/>
      <species id="removedcRaf" name="removedcRaf" compartment="cell" initialAmount="0"/>
      <species id="inactivePKA" name="inactivePKA" compartment="cell" initialAmount="1000"/>
      <species id="EPAC" name="EPAC" compartment="cell" initialAmount="0"/>
      <species id="inactiveEPAC" name="inactiveEPAC" compartment="cell" initialAmount="1000"/>
      <species id="activeRap1" name="activeRap1" compartment="cell" initialAmount="0"/>
      <species id="inactiveRap1" name="inactiveRap1" compartment="cell" initialAmount="1200"/>
      <species id="BRaf" name="BRaf" compartment="cell" initialAmount="1500"/>
      <species id="BRafPP" name="BRafPP" compartment="cell" initialAmount="0"/>
      <species id="activeC3G" name="activeC3G" compartment="cell" initialAmount="0"/>
      <species id="inactiveC3G" name="inactiveC3G" compartment="cell" initialAmount="1200"/>
      <species id="Gap" name="Gap" compartment="cell" initialAmount="2400"/>
      <species id="EPACA" name="EPACA" compartment="cell" initialAmount="0"/>
      <species id="Cilostamide" name="Cilostamide" compartment="cell" initialAmount="0"/>
      <species id="PKAA" name="PKAA" compartment="cell" initialAmount="0"/>
      <species id="degradedEGFR" name="degradedEGFR" compartment="cell" initialAmount="0"/>
    </listOfSpecies>
    <listOfParameters>
      <parameter id="SosKcat" name="SosKcat" value="0.0021806008"/>
      <parameter id="SosKm" name="SosKm" value="8176.5664"/>
    </listOfParameters>
    <listOfReactions>
      <reaction id="reaction_0" name="SosActivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactiveSos"/>
          <speciesReference species="boundEGFR"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="activeSos"/>
          <speciesReference species="boundEGFR"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactiveSos </ci>
                <ci> boundEGFR </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactiveSos </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="0.72711966"/>
            <parameter id="Km" name="Km" value="4145.6067"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_1" name="EGFBingingToTheReceptor (forward)" reversible="false"  >
        <listOfReactants>
          <speciesReference species="EGF"/>
          <speciesReference species="unboundEGFR"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="boundEGFR"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k1 </ci>
              <ci> EGF </ci>
              <ci> unboundEGFR </ci>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k1" name="k1" value="5.8005689"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_2" name="EGFBingingToTheReceptor (backward)" reversible="false"  >
        <listOfReactants>
          <speciesReference species="boundEGFR"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="EGF"/>
          <speciesReference species="unboundEGFR"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k1 </ci>
              <ci> boundEGFR </ci>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k1" name="k1" value="9834.1328"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_3" name="SosDeactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="activeSos"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="inactiveSos"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> activeSos </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> activeSos </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" name="Km" value="20149.951"/>
            <parameter id="V" name="V" value="13.731253"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_4" name="RasActivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactiveRas"/>
          <speciesReference species="activeSos"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="activeRas"/>
          <speciesReference species="activeSos"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactiveRas </ci>
                <ci> activeSos </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactiveRas </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="0.35171144"/>
            <parameter id="Km" name="Km" value="12457.816"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_5" name="RasDeactivation1" reversible="false"  >
        <listOfReactants>
          <speciesReference species="activeRas"/>
          <speciesReference species="Gap"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="inactiveRas"/>
          <speciesReference species="Gap"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> activeRas </ci>
                <ci> Gap </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> activeRas </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="2.2405874"/>
            <parameter id="Km" name="Km" value="1961.7903"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_6" name="cRafActivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="cRaf"/>
          <speciesReference species="activeRas"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="cRafPP"/>
          <speciesReference species="activeRas"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> cRaf </ci>
                <ci> activeRas </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> cRaf </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="1.2990938"/>
            <parameter id="Km" name="Km" value="5930.7869"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_7" name="cRafDeactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="cRafPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="cRaf"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> cRafPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> cRafPP </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" name="Km" value="4238.6527"/>
            <parameter id="V" name="V" value="9815.0778"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_8" name="MEKactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="MEK"/>
          <speciesReference species="cRafPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKPP"/>
          <speciesReference species="cRafPP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> MEK </ci>
                <ci> cRafPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> MEK </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="4.4431196"/>
            <parameter id="Km" name="Km" value="712.53116"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_9" name="MEKdeactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="MEKPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEK"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> MEKPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> MEKPP </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" name="Km" value="10188.05"/>
            <parameter id="V" name="V" value="378.40644"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_10" name="ERKactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="ERK"/>
          <speciesReference species="MEKPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ERKPP"/>
          <speciesReference species="MEKPP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> ERK </ci>
                <ci> MEKPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> ERK </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="0.55434435"/>
            <parameter id="Km" name="Km" value="867.63158"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_11" name="SosInhibition" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactiveSos"/>
          <speciesReference species="ERKPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="removedSos"/>
          <speciesReference species="ERKPP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> SosKcat </ci>
                <ci> inactiveSos </ci>
                <ci> ERKPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> SosKm </ci>
                <ci> inactiveSos </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_12" name="activeSosInhibition" reversible="false"  >
        <listOfReactants>
          <speciesReference species="activeSos"/>
          <speciesReference species="ERKPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="removedSos"/>
          <speciesReference species="ERKPP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> SosKcat </ci>
                <ci> activeSos </ci>
                <ci> ERKPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> SosKm </ci>
                <ci> activeSos </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_13" name="cRafInhibition" reversible="false"  >
        <listOfReactants>
          <speciesReference species="cRaf"/>
          <speciesReference species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="removedcRaf"/>
          <speciesReference species="PKA"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> cRaf </ci>
                <ci> PKA </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> cRaf </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="44.583144"/>
            <parameter id="Km" name="Km" value="3767.4921"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_14" name="PKAActivation1" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactivePKA"/>
          <speciesReference species="PKAA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="PKA"/>
          <speciesReference species="PKAA"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactivePKA </ci>
                <ci> PKAA </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactivePKA </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="6.0646871"/>
            <parameter id="Km" name="Km" value="4395.2106"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_15" name="PKAactivation2" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactivePKA"/>
          <speciesReference species="Cilostamide"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="PKA"/>
          <speciesReference species="Cilostamide"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactivePKA </ci>
                <ci> Cilostamide </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactivePKA </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="0.99474461"/>
            <parameter id="Km" name="Km" value="15124.941"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_16" name="PKADeactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="PKA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="inactivePKA"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> PKA </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> PKA </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" name="Km" value="810.86912"/>
            <parameter id="V" name="V" value="6000.7723"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_17" name="EPACActivation1" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactiveEPAC"/>
          <speciesReference species="EPACA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="EPAC"/>
          <speciesReference species="EPACA"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactiveEPAC </ci>
                <ci> EPACA </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactiveEPAC </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="1.2089732"/>
            <parameter id="Km" name="Km" value="1130.7611"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_18" name="EPACActivation2" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactiveEPAC"/>
          <speciesReference species="Cilostamide"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="EPAC"/>
          <speciesReference species="Cilostamide"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactiveEPAC </ci>
                <ci> Cilostamide </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactiveEPAC </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="4.2268381"/>
            <parameter id="Km" name="Km" value="2251.4608"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_19" name="EPACDeactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="EPAC"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="inactiveEPAC"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> EPAC </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> EPAC </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" name="Km" value="13413.194"/>
            <parameter id="V" name="V" value="994.69179"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_20" name="Rap1ActivationByEPAC" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactiveRap1"/>
          <speciesReference species="EPAC"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="activeRap1"/>
          <speciesReference species="EPAC"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactiveRap1 </ci>
                <ci> EPAC </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactiveRap1 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="0.002914668"/>
            <parameter id="Km" name="Km" value="6808.3228"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_21" name="Rap1Deactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="activeRap1"/>
          <speciesReference species="Gap"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="inactiveRap1"/>
          <speciesReference species="Gap"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> activeRap1 </ci>
                <ci> Gap </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> activeRap1 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="14.645376"/>
            <parameter id="Km" name="Km" value="17991.179"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_22" name="BRafActivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="BRaf"/>
          <speciesReference species="activeRap1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="BRafPP"/>
          <speciesReference species="activeRap1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> BRaf </ci>
                <ci> activeRap1 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> BRaf </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="10.66229"/>
            <parameter id="Km" name="Km" value="5507.8916"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_23" name="BRafDeactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="BRafPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="BRaf"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> BRafPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> BRafPP </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" name="Km" value="549.7896"/>
            <parameter id="V" name="V" value="4.0202064"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_24" name="MEKactivation2" reversible="false"  >
        <listOfReactants>
          <speciesReference species="MEK"/>
          <speciesReference species="BRafPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="MEKPP"/>
          <speciesReference species="BRafPP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> MEK </ci>
                <ci> BRafPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> MEK </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="0.29908629"/>
            <parameter id="Km" name="Km" value="3386.3875"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_25" name="C3GActivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactiveC3G"/>
          <speciesReference species="boundEGFR"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="activeC3G"/>
          <speciesReference species="boundEGFR"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactiveC3G </ci>
                <ci> boundEGFR </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactiveC3G </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="0.21365316"/>
            <parameter id="Km" name="Km" value="10309.918"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_26" name="C3GDeactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="activeC3G"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="inactiveC3G"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> activeC3G </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> activeC3G </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="V" name="V" value="2427.0883"/>
            <parameter id="Km" name="Km" value="3566.0051"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_27" name="Rap1ActivationByC3G" reversible="false"  >
        <listOfReactants>
          <speciesReference species="inactiveRap1"/>
          <speciesReference species="activeC3G"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="activeRap1"/>
          <speciesReference species="activeC3G"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> inactiveRap1 </ci>
                <ci> activeC3G </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactiveRap1 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="4.1908057"/>
            <parameter id="Km" name="Km" value="7631.6306"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_28" name="BRafActivationByRas" reversible="false"  >
        <listOfReactants>
          <speciesReference species="BRaf"/>
          <speciesReference species="activeRas"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="BRafPP"/>
          <speciesReference species="activeRas"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> BRaf </ci>
                <ci> activeRas </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> BRaf </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" name="Kcat" value="28.282332"/>
            <parameter id="Km" name="Km" value="5249.0021"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_29" name="ERKdeactivation" reversible="false"  >
        <listOfReactants>
          <speciesReference species="ERKPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ERK"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> ERKPP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> ERKPP </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" name="Km" value="1124.3293"/>
            <parameter id="V" name="V" value="325.22591"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_30" name="ReceptorDegradation" reversible="false" >
        <listOfReactants>
           <speciesReference species="boundEGFR"/>
        </listOfReactants>
        <listOfProducts>
           <speciesReference species="degradedEGFR"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> boundEGFR </ci>
              <ci> k1 </ci>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k1" name="k1" value="4.299718"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>
