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Editors' Choice

Nancy R. Gough
23 March 2010: ec85.
Monocytes release growth factors that regulate development of the lymphatic system. Abstract »  
Elizabeth M. Adler
23 March 2010: ec86.
Fly macrophages prioritize migratory cues during development. Abstract »  
John F. Foley
23 March 2010: ec87.
Vitamin D receptor signaling enhances responsiveness to T cell receptor stimulation by increasing the abundance of PLC-{gamma}1. Abstract »  
Annalisa M. VanHook
23 March 2010: ec88.
mTOR signaling is implicated in a switch that improves liver regeneration in aged mice. Abstract »  
Peter Stern
23 March 2010: ec89.
Learning incapacity observed during puberty is related to receptor location in the hippocampus. Abstract »  
Nancy R. Gough
23 March 2010: ec90.
A complex containing a calcium channel, a calcium sensor, and a potassium channel regulates neuronal excitability. Abstract »  
Peter Stern
23 March 2010: ec91.
A synaptic protein that regulates postsynaptic AMPA receptor responses has been cloned and functionally characterized. Abstract »  


Research Articles

King-Ho Cheung, Lijuan Mei, Don-On Daniel Mak, Ikuo Hayashi, Takeshi Iwatsubo, David E. Kang, and J. Kevin Foskett
23 March 2010: ra22.
By altering IP3 receptor gating, presenilin mutations associated with familial Alzheimer’s disease increase Ca2+ release from the endoplasmic reticulum. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Manoj Saini, Charles Sinclair, Daniel Marshall, Mauro Tolaini, Shimon Sakaguchi, and Benedict Seddon
23 March 2010: ra23.
Regulated expression of Zap70 determines whether thymocytes develop into CD4+ or CD8+ T cells. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Mark P. Mattson
23 March 2010: pe10.
Mutations in presenilin 1 may exaggerate Ca2+ signaling in neurons, increasing their vulnerability. Abstract »   Full Text »   PDF »  
Balbino Alarcón and Hisse M. van Santen
23 March 2010: pe11.
Specification of T cell lineage in the thymus is controlled by the timing and strength of signaling of the tyrosine kinase Zap70. Abstract »   Full Text »   PDF »  



23 March 2010: er1.
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882